| HSPMdb Accession No | HSPMDB000883 |
| PMID | 24548207 |
| Target | Hsp70 |
| HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
| Organism | Human |
| Localization | Cytosol and nucleus |
| Cellular activity | Antiproliferative activity |
| Compound Name | 45a |
| IUPAC Name | N-(6-Amino-2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethoxy)-6-methoxy-2-(4- methylpiperazin-1-yl)pyrimidin-5-ylthio)pyrimidin-4-yl)acrylamide |
| SMILES | COc1nc(nc(OCCOCCOCCOCCO)c1Sc2nc(N)cc(NC(=O)C=C)n2)N3CCN(C)CC3 |
| Class | 2,5-Thiodipyrimidine and 5-(Phenylthio) pyrimidine acrylamide |
| GI50 (µM) | 50 |
| Site of Interaction | Nucleotide binding domain (allosteric site) |
| Cellular assay | Alamar Blue viability assay |
| Cellular Model | SK-BR-3 |
| Disease | Cancer |
Loading Please Wait ...