HSPMdb Accession NoHSPMDB000868
PMID24548207
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name37
IUPAC NameN-(3-((4,6-Dimethoxy-2-morpholinopyrimidin-5-yl)thio)phenyl)acrylamide
SMILESCOc1nc(nc(OC)c1Sc2cccc(NC(=O)C=C)c2)N3CCOCC3
Class2,5-Thiodipyrimidine and 5-(Phenylthio) pyrimidine acrylamide
GI50 (µM)46.5
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assay Alamar Blue viability assay
Cellular ModelKasumi-1
DiseaseCancer

Structure



HSPMDB000868

37

Physicochemical Properties