HSPMdb Accession NoHSPMDB000866
PMID24548207
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name31
IUPAC NameN-(6-Amino-2-((2-amino-4,6-dimethoxypyrimidin-5-yl)thio)pyrimidin-4-yl)acrylamide
SMILESCOc1nc(N)nc(OC)c1Sc2nc(N)cc(NC(=O)C=C)n2
Class2,5-Thiodipyrimidine and 5-(Phenylthio) pyrimidine acrylamide
GI50 (µM)3.9
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assay Alamar Blue viability assay
Cellular ModelKasumi-1
DiseaseCancer

Structure



HSPMDB000866

31

Physicochemical Properties