HSPMdb Accession No | HSPMDB000852 |
PMID | 29953808 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 59 |
IUPAC Name | 3-(2,6-dichlorobenzyl)-2-((Z)-((E)-3-ethyl-5-(6-ethyl-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4- oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride |
SMILES | [Cl-].CCN1C(=O)C(\S\C1=C/c2scc[n+]2Cc3c(Cl)cccc3Cl)=C4/Sc5cc(CC)ccc5N4C |
Class | Benzothiazole Rhodacyanines derivative |
EC50 (µM) | 0.3 |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Cellular assay | MTT viability assay |
Cellular Model | MEF |
Disease | Cancer |