HSPMdb Accession NoHSPMDB000837
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name58
IUPAC Name3-(2,6-dichlorobenzyl)-2-((Z)-((E)-5-(3,5-dimethylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4- oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride
SMILES[Cl-].CCN1C(=O)C(\S\C1=C/c2scc[n+]2Cc3c(Cl)cccc3Cl)=C4/Sc5ccc(C)cc5N4C
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)0.054
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMDA-MB-231
DiseaseCancer

Structure



HSPMDB000837

58

Physicochemical Properties