HSPMdb Accession NoHSPMDB000834
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name55
IUPAC Name2-((Z)-((E)-3-ethyl-5-(6-methoxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2- ylidene)methyl)-3-(2-methoxybenzyl)thiazol-3-ium chloride
SMILES[Cl-].CCN\1C(=O)C(/SC1=C\c2scc[n+]2Cc3ccccc3OC)=C4\Sc5cc(OC)ccc5N4C
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)0.062
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMDA-MB-231
DiseaseCancer

Structure



HSPMDB000834

55

Physicochemical Properties