HSPMdb Accession NoHSPMDB000822
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name57(JG-345)
IUPAC Name2-((Z)-((E)-3-ethyl-5-(6-ethyl-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-3-(2-(methoxycarbonyl)benzyl)thiazol-3-ium chloride
SMILES[Cl-].CCN\1C(=O)C(/SC1=C\c2scc[n+]2Cc3ccccc3C(=O)OC)=C4\Sc5cc(CC)ccc5N4C
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)0.049
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMCF7
DiseaseCancer

Structure



HSPMDB000822

57(JG-345)

Physicochemical Properties