HSPMdb Accession NoHSPMDB000767
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name32(JG-258)
IUPAC Name3-benzyl-2-((Z)-((E)-3'-ethyl-3-methyl-4'-oxo-3',4,4',5-tetrahydro-2'H,3H-[2,5'-bithiazolylidene]- 2'-ylidene)methyl)thiazol-3-ium chloride
SMILES[Cl-].CCN1C(=O)C(\S\C1=C/c2scc[n+]2Cc3ccccc3)=C4/SCCN4C
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)>20
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMEF
DiseaseCancer

Structure



HSPMDB000767

32(JG-258)

Physicochemical Properties