HSPMdb Accession No | HSPMDB000757 |
PMID | 29953808 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 22 |
IUPAC Name | 2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4-oxothiazolidin-2-ylidene)methyl)-3-(2-chlorobenzyl)thiazol-3-ium chloride |
SMILES | [Cl-].CCN\1C(=O)/C(SC1=C\c2scc[n+]2Cc3ccccc3Cl)=C/4Sc5cc(Cl)ccc5N4C |
Class | Benzothiazole Rhodacyanines derivative |
EC50 (µM) | 0.7 |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Cellular assay | MTT viability assay |
Cellular Model | MEF |
Disease | Cancer |