HSPMdb Accession NoHSPMDB000750
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name15
IUPAC Name3-benzyl-2-((Z)-((E)-3-ethyl-5-(3-methyl-6-(methylthio)benzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride
SMILES[Cl-].CCN1C(=O)C(\S\C1=C/c2scc[n+]2Cc3ccccc3)=C4/Sc5cc(SC)ccc5N4C
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)1.7
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMEF
DiseaseCancer

Structure



HSPMDB000750

15

Physicochemical Properties