HSPMdb Accession No | HSPMDB000728 |
PMID | 29953808 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 26 |
IUPAC Name | 3-(2-bromobenzyl)-2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4- oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride |
SMILES | [Cl-].CCN1C(=O)C(\S\C1=C/c2scc[n+]2Cc3ccccc3Br)=C4/Sc5cc(Cl)ccc5N4C |
Class | Benzothiazole Rhodacyanines derivative |
EC50 (µM) | 0.2 |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Cellular assay | MTT viability assay |
Cellular Model | MDA-MB-231 |
Disease | Cancer |