HSPMdb Accession NoHSPMDB000725
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name23
IUPAC Name2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4-oxothiazolidin-2-ylidene)methyl)-3-(3-chlorobenzyl)thiazol-3-ium chloride
SMILES[Cl-].CCN\1C(=O)/C(SC1=C\c2scc[n+]2Cc3cccc(Cl)c3)=C/4Sc5cc(Cl)ccc5N4C
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)0.51
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMDA-MB-231
DiseaseCancer

Structure



HSPMDB000725

23

Physicochemical Properties