HSPMdb Accession NoHSPMDB000704
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name2
IUPAC Name3-benzyl-2-((Z)-((E)-5-(5-bromo-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4-oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride
SMILES[Cl-].CCN1C(=O)C(\S\C1=C/c2scc[n+]2Cc3ccccc3)=C4/Sc5ccc(Br)cc5N4C
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)0.11
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMDA-MB-231
DiseaseCancer

Structure



HSPMDB000704

2

Physicochemical Properties