HSPMdb Accession NoHSPMDB000695
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name26
IUPAC Name3-(2-bromobenzyl)-2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4- oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride
SMILES[Cl-].CCN1C(=O)C(\S\C1=C/c2scc[n+]2Cc3ccccc3Br)=C4/Sc5cc(Cl)ccc5N4C
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)0.19
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMCF7
DiseaseCancer

Structure



HSPMDB000695

26

Physicochemical Properties