HSPMdb Accession NoHSPMDB000686
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name17
IUPAC Name3-benzyl-2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-cyclopropyl-4-oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride
SMILES[Cl-].CN1C(/Sc2cc(Cl)ccc12)=C3\S\C(=C/c4scc[n+]4Cc5ccccc5)N(C6CC6)C3=O
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)0.33
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMCF7
DiseaseCancer

Structure



HSPMDB000686

17

Physicochemical Properties