HSPMdb Accession No | HSPMDB000686 |
PMID | 29953808 |
Target | Hsp70 |
HSP Name | Hsc70 (HSPA8) and Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Cellular activity | Antiproliferative activity |
Compound Name | 17 |
IUPAC Name | 3-benzyl-2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-cyclopropyl-4-oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride |
SMILES | [Cl-].CN1C(/Sc2cc(Cl)ccc12)=C3\S\C(=C/c4scc[n+]4Cc5ccccc5)N(C6CC6)C3=O |
Class | Benzothiazole Rhodacyanines derivative |
EC50 (µM) | 0.33 |
Site of Interaction | Nucleotide binding domain (allosteric site) |
Cellular assay | MTT viability assay |
Cellular Model | MCF7 |
Disease | Cancer |