HSPMdb Accession NoHSPMDB000685
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name16
IUPAC Name2-((Z)-((E)-3-allyl-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-3-benzylthiazol-3-ium chloride
SMILES[Cl-].CN1C(\Sc2cc(Cl)ccc12)=C3/SC(=C\c4scc[n+]4Cc5ccccc5)/N(CC=C)C3=O
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)0.17
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMCF7
DiseaseCancer

Structure



HSPMDB000685

16

Physicochemical Properties