HSPMdb Accession NoHSPMDB000682
PMID29953808
TargetHsp70
HSP NameHsc70 (HSPA8) and Hsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound Name13
IUPAC Name3-benzyl-2-((Z)-((E)-3-ethyl-5-(5-methoxy-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazo lidin-2-ylidene)methyl)thiazol-3-ium chloride
SMILES[Cl-].CCN1C(=O)C(\S\C1=C/c2scc[n+]2Cc3ccccc3)=C4/Sc5ccc(OC)cc5N4C
ClassBenzothiazole Rhodacyanines derivative
EC50 (µM)0.37
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMCF7
DiseaseCancer

Structure



HSPMDB000682

13

Physicochemical Properties