| HSPMdb Accession No | HSPMDB000649 |
| PMID | 24239008 |
| Target | Hsp70 |
| HSP Name | Hsc70 (HSPA8) |
| Organism | Human |
| Localization | Cytosol and nucleus |
| Enzymatic activity | Inhibition of chaperone activity |
| Compound Name | YK5 |
| IUPAC Name | N-(6-amino-2-{[4,6-dimethoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]sulfanyl}pyrimidin-4-yl)prop-2-enamide |
| SMILES | COC1=NC(=NC(OC)=C1SC1=NC(N)=CC(NC(=O)C=C)=N1)N1CCN(C)CC1 |
| Class | Structure based design |
| % Enzymatic Inhibition/Fold Change | 90% inhibition at 100 uM |
| Site of Interaction | Nucleotide binding domain |
| Type of Enzymatic Assay | Refolding assay (luciferase) |
| Disease | Cancer |
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