HSPMdb Accession NoHSPMDB000647
PMID23819499
TargetHsp70
HSP NameDnaK
OrganismBacteria
LocalizationCytosol and membrane
Enzymatic activityBinding affinity (ATP-bound DnaK)
Compound Name Zafirlukast (Zaf)
IUPAC Namecyclopentyl N-[3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methylindol-5-yl]carbamate
SMILESCC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(C=C2)CC3=CN(C4=C3C=C(C=C4)NC(=O)OC5CCCC5)C)OC
ClassLibrary assembled at the University of Michigan's Center for Chemical Genomics
Kd (µM)>100
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayIntrisic Trp fluortescence

Structure



HSPMDB000647

Zafirlukast (Zaf)

Physicochemical Properties