HSPMdb Accession No | HSPMDB000582 |
PMID | 19195901 |
Target | Hsp70 |
HSP Name | PfHsp70 |
Organism | Plasmodium falciparum |
Localization | Cytosol and nucleus |
Cellular activity | Antiparasitic activity (inhibition of [3H]hypoxanthine uptake) |
Compound Name | JAB75 |
IUPAC Name | methyl 6-benzyl-4-(naphthalen-2-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
SMILES | COC(=O)C1=C(CC2=CC=CC=C2)NC(=O)NC1C1=CC2=C(C=CC=C2)C=C1 |
Class | Pyrimidinone amide |
IC50 (µM) | 0.3 |
Cellular assay | [3H]hypoxanthine uptake assay |
Cellular Model | P. falciparum |
Disease | Malaria |