HSPMdb Accession NoHSPMDB000582
PMID19195901
TargetHsp70
HSP NamePfHsp70
Organism Plasmodium falciparum
LocalizationCytosol and nucleus
Cellular activity Antiparasitic activity (inhibition of [3H]hypoxanthine uptake)
Compound NameJAB75
IUPAC Namemethyl 6-benzyl-4-(naphthalen-2-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
SMILESCOC(=O)C1=C(CC2=CC=CC=C2)NC(=O)NC1C1=CC2=C(C=CC=C2)C=C1
Class Pyrimidinone amide
IC50 (µM)0.3
Cellular assay[3H]hypoxanthine uptake assay
Cellular ModelP. falciparum
DiseaseMalaria

Structure



HSPMDB000582

JAB75

Physicochemical Properties