HSPMdb Accession NoHSPMDB000578
PMID19195901
TargetHsp70
HSP NamePfHsp70
Organism Plasmodium falciparum
LocalizationCytosol and nucleus
Cellular activity Antiparasitic activity (inhibition of [3H]hypoxanthine uptake)
Compound NameMAL2-61
IUPAC Nameethyl 1-benzyl-6-methyl-4-{2-[(2-nitrobenzenesulfonyl)oxy]phenyl}-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
SMILESCCOC(=O)C1=C(C)N(CC2=CC=CC=C2)C(=O)NC1C1=CC=CC=C1OS(=O)(=O)C1=C(C=CC=C1)[N+]([O-])=O
Class Pyrimidinone amide
IC50 (µM)0.1
Cellular assay[3H]hypoxanthine uptake assay
Cellular ModelP. falciparum
DiseaseMalaria

Structure



HSPMDB000578

MAL2-61

Physicochemical Properties