HSPMdb Accession No | HSPMDB000578 |
PMID | 19195901 |
Target | Hsp70 |
HSP Name | PfHsp70 |
Organism | Plasmodium falciparum |
Localization | Cytosol and nucleus |
Cellular activity | Antiparasitic activity (inhibition of [3H]hypoxanthine uptake) |
Compound Name | MAL2-61 |
IUPAC Name | ethyl 1-benzyl-6-methyl-4-{2-[(2-nitrobenzenesulfonyl)oxy]phenyl}-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
SMILES | CCOC(=O)C1=C(C)N(CC2=CC=CC=C2)C(=O)NC1C1=CC=CC=C1OS(=O)(=O)C1=C(C=CC=C1)[N+]([O-])=O |
Class | Pyrimidinone amide |
IC50 (µM) | 0.1 |
Cellular assay | [3H]hypoxanthine uptake assay |
Cellular Model | P. falciparum |
Disease | Malaria |