HSPMdb Accession NoHSPMDB000576
PMID19195901
TargetHsp70
HSP NamePfHsp70
Organism Plasmodium falciparum
LocalizationCytosol and nucleus
Cellular activity Antiparasitic activity (inhibition of [3H]hypoxanthine uptake)
Compound NameMAL2-29
IUPAC Name6-[5-(ethoxycarbonyl)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl]hexanoic acid
SMILESCCOC(=O)C1=C(C)N(CCCCCC(O)=O)C(=O)NC1C1=CC=CC(=C1)[N+]([O-])=O
Class Pyrimidinone amide
IC50 (µM)1.6
Cellular assay[3H]hypoxanthine uptake assay
Cellular ModelP. falciparum
DiseaseMalaria

Structure



HSPMDB000576

MAL2-29

Physicochemical Properties