HSPMdb Accession NoHSPMDB000575
PMID19195901
TargetHsp70
HSP NamePfHsp70
Organism Plasmodium falciparum
LocalizationCytosol and nucleus
Cellular activity Antiparasitic activity (inhibition of [3H]hypoxanthine uptake)
Compound NameDMT2264
IUPAC Namebenzyl 4-{[1,1'-biphenyl]-4-yl}-1-(5-{[(butylcarbamoyl)(cyclohexyl)methyl](hexyl)carbamoyl}pentyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
SMILESCCCCCCN(C(C1CCCCC1)C(=O)NCCCC)C(=O)CCCCCN1C(=O)NC(C2=CC=C(C=C2)C2=CC=CC=C2)C(C(=O)OCC2=CC=CC=C2)=C1C
Class Pyrimidinone amide
IC50 (µM)1.1
Cellular assay[3H]hypoxanthine uptake assay
Cellular ModelP. falciparum
DiseaseMalaria

Structure



HSPMDB000575

DMT2264

Physicochemical Properties