HSPMdb Accession NoHSPMDB000547
PMID19195901
TargetHsp70
HSP NamePfHsp70
Organism Plasmodium falciparum
LocalizationCytosol and nucleus
Enzymatic activityInhibition of ATPase activity
Compound NameDMT3024
IUPAC Namebenzyl 1-{5-[({[1,1'-biphenyl]-4-yl}(butylcarbamoyl)methyl)[2-(morpholin-4-yl)ethyl]carbamoyl]pentyl}-6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
SMILESCCCCNC(=O)C(N(CCN1CCOCC1)C(=O)CCCCCN1C(=O)NC(C2=CC=C(C=C2)[N+]([O-])=O)C(C(=O)OCC2=CC=CC=C2)=C1C)C1=CC=C(C=C1)C1=CC=CC=C1
Class Pyrimidinone amide
% Enzymatic Inhibition/Fold Change0.73
Type of Enzymatic AssayATPase assay
DiseaseMalaria

Structure



HSPMDB000547

DMT3024

Physicochemical Properties