HSPMdb Accession NoHSPMDB000541
PMID23472668
TargetHsp70
HSP NameHsc70 (HSPA8)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound NameYM-02
IUPAC Name3-ethyl-5-[(2E)-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
SMILESCCN1C(=S)S\C(C1=O)=C1\SC2=C(C=CC=C2)N1C
ClassRhodacyanine derivative
EC50 (µM)>30
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelHeLa
DiseaseCancer

Structure



HSPMDB000541

YM-02

Physicochemical Properties