HSPMdb Accession NoHSPMDB000533
PMID23472668
TargetHsp70
HSP NameHsc70 (HSPA8)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound NameYM-08
IUPAC Name(2Z)-3-ethyl-5-[(2E)-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-2-[(pyridin-2-yl)methylidene]-1,3-thiazolidin-4-one
SMILESCCN1\C(S\C(C1=O)=C1\SC2=C(C=CC=C2)N1C)=C\C1=NC=CC=C1
ClassRhodacyanine derivative
EC50 (µM)8.5
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMDA-MB-231
DiseaseCancer

Structure



HSPMDB000533

YM-08

Physicochemical Properties