HSPMdb Accession NoHSPMDB000532
PMID23472668
TargetHsp70
HSP NameHsc70 (HSPA8)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound NameYM-01
IUPAC Name2-{[(2Z)-3-ethyl-5-[(2E)-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-4-oxo-1,3-thiazolidin-2-ylidene]methyl}-1-methylpyridin-1-ium chloride
SMILES[Cl-].CCN1\C(S\C(C1=O)=C1\SC2=C(C=CC=C2)N1C)=C\C1=[N+](C)C=CC=C1
ClassRhodacyanine derivative
EC50 (µM)2
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMDA-MB-231
DiseaseCancer

Structure



HSPMDB000532

YM-01

Physicochemical Properties