HSPMdb Accession NoHSPMDB000521
PMID23472668
TargetHsp70
HSP NameHsc70 (HSPA8)
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound NameYM-03
IUPAC Name3-ethyl-5-[(2E)-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-2-(methylsulfanyl)-4-oxo-4,5-dihydro-1,3-thiazol-3-ium
SMILESCC[N+]1=C(SC)S\C(C1=O)=C1\SC2=C(C=CC=C2)N1C
ClassRhodacyanine derivative
EC50 (µM)>30
Site of InteractionNucleotide binding domain (allosteric site)
Cellular assayMTT viability assay
Cellular ModelMCF7
DiseaseCancer

Structure



HSPMDB000521

YM-03

Physicochemical Properties