HSPMdb Accession NoHSPMDB000510
PMID23472668
TargetHsp70
HSP NameHsc70 (HSPA8)
OrganismHuman
LocalizationCytosol and nucleus
Enzymatic activityBinding affinity
Compound NameMKT-077
IUPAC Name2-{[(2Z)-3-ethyl-5-[(2E)-3-methyl-2,3-dihydro-1,3-benzothiazol-2-ylidene]-4-oxo-1,3-thiazolidin-2-ylidene]methyl}-1-methylpyridin-1-ium chloride
SMILES[Cl-].CCN1\C(S\C(C1=O)=C1\SC2=C(C=CC=C2)N1C)=C\C1=[N+](C)C=CC=C1
Class Rhodacyanine
IC50 (µM)6.4
Site of InteractionNucleotide binding domain (allosteric site)
Type of Enzymatic AssayEnzyme-linked immunosorbent assay (ELISA)
DiseaseAlzheimers disease

Structure



HSPMDB000510

MKT-077

Physicochemical Properties