HSPMdb Accession No | HSPMDB000509 |
PMID | 23177194 |
Target | Hsp70 |
HSP Name | Hsp72 (HSPA1A) |
Organism | Human |
Localization | Cytosol and nucleus |
Enzymatic activity | Inhibition of ATPase activity |
Compound Name | Methylene Blue |
IUPAC Name | [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride |
SMILES | CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-] |
Class | Dihydropyrimidine derivative |
% Enzymatic Inhibition/Fold Change | 37.50% |
Site of Interaction | Irreversibly inhibits by oxidizing Cys306 |
Type of Enzymatic Assay | ATPase assay |