HSPMdb Accession NoHSPMDB000509
PMID23177194
TargetHsp70
HSP NameHsp72 (HSPA1A)
OrganismHuman
LocalizationCytosol and nucleus
Enzymatic activityInhibition of ATPase activity
Compound NameMethylene Blue
IUPAC Name[7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride
SMILESCN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]
ClassDihydropyrimidine derivative
% Enzymatic Inhibition/Fold Change37.50%
Site of InteractionIrreversibly inhibits by oxidizing Cys306
Type of Enzymatic AssayATPase assay

Structure



HSPMDB000509

Methylene Blue

Physicochemical Properties