HSPMdb Accession NoHSPMDB000498
PMID25500222
TargetHsp70
HSP NameHsp70i
OrganismHuman
Localization Cell surface
Enzymatic activityInhibition of ATP binding
Cellular activityInhibition of tumor growth
Compound NameHS-72
IUPAC Name ((S)-N-(1-propyl-1Hbenzo[d]imidazol-2-yl)-1-(pyrazin-2-yl)piperidine-3-carboxamide)
SMILESCCCn1c(NC(=O)[C@H]2CCCN(C2)c3cnccn3)nc4ccccc14
ClassPurine analogue
Site of InteractionAllosteric site
Type of Enzymatic AssayFluorescence linked enzyme chemoproteomic strategy (FLECS)
HSP client protein assayHer2 degradation assay
Cellular ModelHeLa
DiseaseCancer

Structure



HSPMDB000498

HS-72

Physicochemical Properties