HSPMdb Accession NoHSPMDB000495
PMID29953808
TargetHsp70
HSP NameHsp70
OrganismHuman
LocalizationCytosol
Enzymatic activityInhibition of HSP 70 BAG interaction
Compound NameJG-345
IUPAC Name2-((Z)-((E)-3-ethyl-5-(6-ethyl-3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-3-(2-(methoxycarbonyl)benzyl)thiazol-3-ium chloride
SMILES[Cl-].CCN\1C(=O)C(/SC1=C\c2scc[n+]2Cc3ccccc3C(=O)OC)=C4\Sc5cc(CC)ccc5N4C
ClassBenzothiazole Rhodacyanines derivative
Ki (µM)1.11
Site of InteractionAllosteric site
Type of Enzymatic AssayHsp70-BAG interaction assay
DiseaseCancer

Structure



HSPMDB000495

JG-345

Physicochemical Properties