HSPMdb Accession NoHSPMDB000490
PMID14966137
TargetHsp70
HSP NameHsp73
OrganismPorcine
LocalizationCytosol
Enzymatic activityInhibition of chaperone activity
Compound NameGentamycin
IUPAC Name2-[4,6-diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
SMILESCC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC
ClassAminoglycoside antibiotic
% Enzymatic Inhibition/Fold Change100% at 500 uM
Site of InteractionC-terminal domain
Type of Enzymatic AssaySubstrate aggregation suppression assay

Structure



HSPMDB000490

Gentamycin

Physicochemical Properties