HSPMdb Accession NoHSPMDB000476
PMID19256508
TargetHsp70
HSP NameHsc70
OrganismHuman
LocalizationCytosol
Cellular activityAntiproliferative activity
Compound Name17
IUPAC Name(2R,3R,4S,5R)-2-{6-Amino-8-[(quinolin-6-ylmethyl)-amino]-purin-9-yl}-5-(3,4,5- trifluorobenzyloxymethyl)-tetrahydrofuran-3,4-diol
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4cc(F)c(F)c(F)c4)[C@@H](O)[C@H]3O)c(NCc5ccc6ncccc6c5)nc12
ClassAdenosine derivative
GI50 (µM)18
Site of InteractionNucleotide binding domain
Cellular assayMTT viability assay
Cellular ModelHCT116

Structure



HSPMDB000476

17

Physicochemical Properties