HSPMdb Accession NoHSPMDB000475
PMID19256508
TargetHsp70
HSP NameHsc70
OrganismHuman
LocalizationCytosol
Cellular activityAntiproliferative activity
Compound Name16
IUPAC Name(2R,3R,4S,5R)-2-{6-Amino-8-[(quinolin-6-ylmethyl)-amino]-purin-9-yl}-5-(4-trifluoromethylbenzyloxymethyl)-tetrahydrofuran-3,4-diol
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C(F)(F)F)[C@@H](O)[C@H]3O)c(NCc5ccc6ncccc6c5)nc12
ClassAdenosine derivative
GI50 (µM)27
Site of InteractionNucleotide binding domain
Cellular assayMTT viability assay
Cellular ModelHCT116

Structure



HSPMDB000475

16

Physicochemical Properties