HSPMdb Accession NoHSPMDB000473
PMID19256508
TargetHsp70
HSP NameHsc70
OrganismHuman
LocalizationCytosol
Cellular activityAntiproliferative activity
Compound Name14
IUPAC Name(2R,3R,4S,5R)-2-[6-Amino-8-(3,4-dichlorobenzylamino)-purin-9-yl]-5-(3,4,5-trifluorobenzyloxymethyl)-tetrahydrofuran-3,4-diol
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4cc(F)c(F)c(F)c4)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12
ClassAdenosine derivative
GI50 (µM)13
Site of InteractionNucleotide binding domain
Cellular assayMTT viability assay
Cellular ModelHCT116

Structure



HSPMDB000473

14

Physicochemical Properties