HSPMdb Accession No | HSPMDB000471 |
PMID | 19256508 |
Target | Hsp70 |
HSP Name | Hsc70 |
Organism | Human |
Localization | Cytosol |
Cellular activity | Antiproliferative activity |
Compound Name | 12 |
IUPAC Name | 4-{(2R,3S,4R,5R)-5-[6-Amino-8-(3,4-dichlorobenzylamino)purin-9-yl]-3,4- dihydroxytetrahydrofuran-2-ylmethoxymethyl}benzonitrile |
SMILES | Nc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12 |
Class | Adenosine derivative |
GI50 (µM) | 5 |
Site of Interaction | Nucleotide binding domain |
Cellular assay | MTT viability assay |
Cellular Model | HCT116 |