HSPMdb Accession NoHSPMDB000471
PMID19256508
TargetHsp70
HSP NameHsc70
OrganismHuman
LocalizationCytosol
Cellular activityAntiproliferative activity
Compound Name12
IUPAC Name4-{(2R,3S,4R,5R)-5-[6-Amino-8-(3,4-dichlorobenzylamino)purin-9-yl]-3,4- dihydroxytetrahydrofuran-2-ylmethoxymethyl}benzonitrile
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12
ClassAdenosine derivative
GI50 (µM)5
Site of InteractionNucleotide binding domain
Cellular assayMTT viability assay
Cellular ModelHCT116

Structure



HSPMDB000471

12

Physicochemical Properties