HSPMdb Accession NoHSPMDB000462
PMID19256508
TargetHsp70
HSP NameHsc70
OrganismHuman
LocalizationCytosol
Enzymatic activityBinding affinity
Compound Name17
IUPAC Name(2R,3R,4S,5R)-2-{6-Amino-8-[(quinolin-6-ylmethyl)-amino]-purin-9-yl}-5-(3,4,5- trifluorobenzyloxymethyl)-tetrahydrofuran-3,4-diol
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4cc(F)c(F)c(F)c4)[C@@H](O)[C@H]3O)c(NCc5ccc6ncccc6c5)nc12
ClassAdenosine derivative
Kd (µM)0.12
Site of InteractionNucleotide binding domain
Type of Enzymatic AssayHSP70 Biacore Direct Binding Assay

Structure



HSPMDB000462

17

Physicochemical Properties