HSPMdb Accession NoHSPMDB000452
PMID19256508
TargetHsp70
HSP NameHsc70
OrganismHuman
LocalizationCytosol
Enzymatic activityInhibition of ATP binding
Compound Name15
IUPAC Name4-((2R,3S,4R,5R)-5-{6-Amino-8-[(quinolin-6-ylmethyl)-amino]-purin-9-yl}-3,4-dihydroxytetrahydrofuran-2-ylmethoxymethyl)-benzonitrile
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc6ncccc6c5)nc12
ClassAdenosine derivative
IC50 (µM)0.9
Site of InteractionNucleotide binding domain
Type of Enzymatic Assay Fluorescence polarization (FP) assay

Structure



HSPMDB000452

15

Physicochemical Properties