HSPMdb Accession NoHSPMDB000450
PMID19256508
TargetHsp70
HSP NameHsc70
OrganismHuman
LocalizationCytosol
Enzymatic activityInhibition of ATP binding
Compound Name13
IUPAC Name4-[(2R,3S,4R,5R)-5-(6-Amino-8-benzylamino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2- ylmethoxymethyl]-benzonitrile
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccccc5)nc12
ClassAdenosine derivative
IC50 (µM)1.3
Site of InteractionNucleotide binding domain
Type of Enzymatic Assay Fluorescence polarization (FP) assay

Structure



HSPMDB000450

13

Physicochemical Properties