HSPMdb Accession NoHSPMDB000445
PMID19256508
TargetHsp70
HSP NameHsc70
OrganismHuman
LocalizationCytosol
Enzymatic activityInhibition of ATP binding
Compound Name8
IUPAC Name(2R,3R,4S,5R)-2-{6-Amino-8-[(benzo[1,3]dioxol-5-ylmethyl)-amino]-purin-9-yl}-5- hydroxymethyltetrahydrofuran-3,4-diol
SMILESNc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(NCc4ccc5OCOc5c4)nc12
ClassAdenosine derivative
IC50 (µM)4.9
Site of InteractionNucleotide binding domain
Type of Enzymatic Assay Fluorescence polarization (FP) assay

Structure



HSPMDB000445

8

Physicochemical Properties