HSPMdb Accession NoHSPMDB000435
PMID25772468
TargetHsp70
HSP NameHsp70
OrganismHuman
LocalizationCytosol
Cellular activityAntiproliferative activity
Compound NameApoptozole (Az)
IUPAC Name4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)imidazol-1-yl]methyl]benzamide
SMILESCOC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC
ClassImidazole
IC50 (µM)6
Site of InteractionNucleotide binding domain
Cellular assayMTT viability assay
Cellular ModelHeLa
DiseaseCancer

Structure



HSPMDB000435

Apoptozole (Az)

Physicochemical Properties