HSPMdb Accession NoHSPMDB000431
PMID25772468
TargetHsp70
HSP NameHsp70
OrganismHuman
LocalizationCytosol
Enzymatic activityInhibition of ATPase activity
Compound Name13
IUPAC NameN-{2-[2-(2-aminoethoxy)ethoxy]ethyl}-4-({2-[3-(difluoromethyl)-5-(trifluoromethyl)phenyl]-4,5-bis(naphthalen-2-yl)-1H-imidazol-1-yl}methyl)benzamide
SMILESNCCOCCOCCNC(=O)C1=CC=C(CN2C(=NC(=C2C2=CC3=C(C=CC=C3)C=C2)C2=CC=C3C=CC=CC3=C2)C2=CC(=CC(=C2)C(F)(F)F)C(F)F)C=C1
ClassImidazole library
% Enzymatic Inhibition/Fold Change10% at 100 uM
Type of Enzymatic AssayATPase assay
DiseaseCancer

Structure



HSPMDB000431

13

Physicochemical Properties