HSPMdb Accession No | HSPMDB000417 |
PMID | 25772468 |
Target | Hsp70 |
HSP Name | Hsp70 |
Organism | Human |
Localization | Cytosol |
Enzymatic activity | Inhibition of ATPase activity |
Compound Name | Apoptozole (Az) |
IUPAC Name | 4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)imidazol-1-yl]methyl]benzamide |
SMILES | COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC |
Class | Imidazole |
% Enzymatic Inhibition/Fold Change | 32% at 100 uM |
Site of Interaction | Nucleotide binding domain |
Type of Enzymatic Assay | ATPase assay |
Disease | Cancer |