HSPMdb Accession NoHSPMDB000367
PMID21426241
TargetHsp70
HSP NamePfHsp70-1
Organism Plasmodium falciparum
LocalizationCytosol and nucleus
Enzymatic activityInhibition of protein aggregation activity
Compound Name Lapachol
IUPAC Name2-hydroxy-3-(3-methylbut-2-en-1-yl)-1,4-dihydronaphthalene-1,4-dione
SMILESCC(C)=CCC1=C(O)C(=O)C2=C(C=CC=C2)C1=O
Class1,4 naphthoquinone
% Enzymatic Inhibition/Fold Change>90% at 300 uM
Type of Enzymatic Assay Substrate aggregation suppression assay
DiseaseMalaria

Structure



HSPMDB000367

Lapachol

Physicochemical Properties