HSPMdb Accession No | HSPMDB000367 |
PMID | 21426241 |
Target | Hsp70 |
HSP Name | PfHsp70-1 |
Organism | Plasmodium falciparum |
Localization | Cytosol and nucleus |
Enzymatic activity | Inhibition of protein aggregation activity |
Compound Name | Lapachol |
IUPAC Name | 2-hydroxy-3-(3-methylbut-2-en-1-yl)-1,4-dihydronaphthalene-1,4-dione |
SMILES | CC(C)=CCC1=C(O)C(=O)C2=C(C=CC=C2)C1=O |
Class | 1,4 naphthoquinone |
% Enzymatic Inhibition/Fold Change | >90% at 300 uM |
Type of Enzymatic Assay | Substrate aggregation suppression assay |
Disease | Malaria |