HSPMdb Accession NoHSPMDB000365
PMID21426241
TargetHsp70
HSP NamePfHsp70-1
Organism Plasmodium falciparum
LocalizationCytosol and nucleus
Enzymatic activityInhibition of protein aggregation activity
Compound NameMalonganenone B
IUPAC NameN-methyl-4-(N-methylformamido)-1-[(2E,6E,11Z)-3,7,11,15-tetramethyl-13-oxohexadeca-2,6,11-trien-1-yl]-1H-imidazole-5-carboxamide
SMILES[H]C(=O)N(C)C1=C(N(C\C=C(/C)CC\C=C(/C)CCC\C(C)=C/C(=O)CC(C)C)C=N1)C(=O)NC
Class Marine tetraprenylated alkaloid
% Enzymatic Inhibition/Fold Change>90% at 300 uM
Type of Enzymatic Assay Substrate aggregation suppression assay
DiseaseMalaria

Structure



HSPMDB000365

Malonganenone B

Physicochemical Properties