HSPMdb Accession No | HSPMDB000365 |
PMID | 21426241 |
Target | Hsp70 |
HSP Name | PfHsp70-1 |
Organism | Plasmodium falciparum |
Localization | Cytosol and nucleus |
Enzymatic activity | Inhibition of protein aggregation activity |
Compound Name | Malonganenone B |
IUPAC Name | N-methyl-4-(N-methylformamido)-1-[(2E,6E,11Z)-3,7,11,15-tetramethyl-13-oxohexadeca-2,6,11-trien-1-yl]-1H-imidazole-5-carboxamide |
SMILES | [H]C(=O)N(C)C1=C(N(C\C=C(/C)CC\C=C(/C)CCC\C(C)=C/C(=O)CC(C)C)C=N1)C(=O)NC |
Class | Marine tetraprenylated alkaloid |
% Enzymatic Inhibition/Fold Change | >90% at 300 uM |
Type of Enzymatic Assay | Substrate aggregation suppression assay |
Disease | Malaria |