HSPMdb Accession No | HSPMDB000364 |
PMID | 21426241 |
Target | Hsp70 |
HSP Name | PfHsp70-1 |
Organism | Plasmodium falciparum |
Localization | Cytosol and nucleus |
Enzymatic activity | Inhibition of protein aggregation activity |
Compound Name | Malonganenone A |
IUPAC Name | 3-methyl-7-[(2E,6E,11Z)-3,7,11,15-tetramethyl-13-oxohexadeca-2,6,11-trien-1-yl]-6,7-dihydro-3H-purin-6-one |
SMILES | CC(C)CC(=O)\C=C(\C)CCC\C(C)=C\CC\C(C)=C\CN1C=NC2=C1C(=O)N=CN2C |
Class | Marine tetraprenylated alkaloid |
% Enzymatic Inhibition/Fold Change | >90% at 300 uM |
Type of Enzymatic Assay | Substrate aggregation suppression assay |
Disease | Malaria |