HSPMdb Accession NoHSPMDB000364
PMID21426241
TargetHsp70
HSP NamePfHsp70-1
Organism Plasmodium falciparum
LocalizationCytosol and nucleus
Enzymatic activityInhibition of protein aggregation activity
Compound NameMalonganenone A
IUPAC Name3-methyl-7-[(2E,6E,11Z)-3,7,11,15-tetramethyl-13-oxohexadeca-2,6,11-trien-1-yl]-6,7-dihydro-3H-purin-6-one
SMILESCC(C)CC(=O)\C=C(\C)CCC\C(C)=C\CC\C(C)=C\CN1C=NC2=C1C(=O)N=CN2C
Class Marine tetraprenylated alkaloid
% Enzymatic Inhibition/Fold Change>90% at 300 uM
Type of Enzymatic Assay Substrate aggregation suppression assay
DiseaseMalaria

Structure



HSPMDB000364

Malonganenone A

Physicochemical Properties