HSPMdb Accession NoHSPMDB000353
PMID18164205
TargetHsp70
HSP NameHsp70
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound NameDMT003024
IUPAC Namebenzyl 3-[6-[[2-(butylamino)-2-oxo-1-(4-phenylphenyl)ethyl]-(2-morpholin-4-ylethyl)amino]-6-oxohexyl]-4-methyl-6-(4-nitrophenyl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate
SMILESCCCCNC(=O)C(N(CCN1CCOCC1)C(=O)CCCCCN2C(=O)NC(c3ccc(cc3)[N+]([O-])=O)C(=C2C)C(=O)OCc4ccccc4)c5ccc(cc5)c6ccccc6
ClassDihydropyrimidine derivative
GI50 (µM)>50
Cellular assayMTT viability assay
Cellular ModelSK-BR-3
DiseaseCancer

Structure



HSPMDB000353

DMT003024

Physicochemical Properties