HSPMdb Accession NoHSPMDB000330
PMID18164205
TargetHsp70
HSP NameHsp70
OrganismHuman
LocalizationCytosol and nucleus
Cellular activityAntiproliferative activity
Compound NameDMT003092
IUPAC Namebenzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]-hexylamino]-6-oxohexyl]-4-methyl-6-(4-nitrophenyl)-2-oxo-1,6-dihydropyrimidine-5-carboxylate
SMILESCCCCCCN(C(C(=O)NCCCC)c1ccc(OCC(=O)OC)c(c1)C(=O)OC)C(=O)CCCCCN2C(=O)NC(c3ccc(cc3)[N+]([O-])=O)C(=C2C)C(=O)OCc4ccccc4
ClassDihydropyrimidine derivative
GI50 (µM)6.9
Cellular assayMTT viability assay
Cellular ModelSK-BR-3
DiseaseCancer

Structure



HSPMDB000330

DMT003092

Physicochemical Properties