HSPMdb Accession NoHSPMDB000202
PMID15448148
TargetHsp70
HSP NameSsa1p
OrganismYeast
LocalizationCytosol
Enzymatic activityActivation of ATPase activity (endogenous)
Compound NameMAL3-101
IUPAC NameBenzyl 4-([1,1?-biphenyl]-4-yl)-1-(6-((2-(butylamino)-1-(4-(2-methoxy-2-oxoethoxy)-3-(methoxycarbonyl)phenyl)-2-oxoethyl)(hexyl)amino)-6-oxohexyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
SMILESO=C(C1=C(C)N(CCCCCC(N(C(C2=CC=C(OCC(OC)=O)C(C(OC)=O)=C2)C(NCCCC)=O)CCCCCC)=O)C(NC1C3=CC=C(C4=CC=CC=C4)C=C3)=O)OCC5=CC=CC=C5
ClassDihydropyrimidine derivative
% Enzymatic Inhibition/Fold ChangeFold change 1.2 (at 0.6 mM)
Site of InteractionInterface between Hsp70 and Hsp40
Type of Enzymatic AssayATPase assay

Structure



HSPMDB000202

MAL3-101

Physicochemical Properties